Life I/O (“I/O” as in “on/off”) is the first supplement launched by the new longevity-focused company Pro2col, which has recently drawn attention in the biohacking scene with its app-based coaching platform.
The promise: An intelligent blend of ingredients for a longer, healthier life – formulated based on recent insights in mitochondrial medicine, methylation, and cellular health.
With a monthly price tag of €89.90, Life I/O clearly positions itself as a premium product. The formula includes striking ingredients like CMED 100, Ergothioneine, Spermidine, NR, and PQQ – all of which are increasingly discussed in the context of next-generation longevity supplements.
So, what does this combination actually deliver? How does Life I/O compare to other longevity products – and is the price justified?
This article offers a comprehensive look at the ingredients, evidence, and practical value of Life I/O – with our own experience to follow once testing becomes possible.
Ingredients & Composition
Life I/O combines established longevity nutrients with modern antioxidants, mitochondrial activators, and methylation-supporting cofactors.
The goal? A well-rounded support for cellular health, targeting both energy production and regeneration pathways.
Here’s a breakdown of the active ingredients and their roles:
| Ingredient | Function | Category |
|---|---|---|
| NR (Niagen®) | Boosts NAD+ levels, supports cellular energy | Mitochondrial booster |
| PQQ | Promotes mitochondrial biogenesis | Mitochondrial booster |
| CoQ10 | ATP production & antioxidant protection | Energy / Antioxidant |
| L-Ergothioneine | Protects liver, nerves, and heart tissue | Antioxidant |
| Quercetin | Anti-inflammatory, synergistic effects | Antioxidant |
| Trans-Resveratrol | Activates sirtuins, supports DNA stability | Longevity molecule |
| Luteolin | Neuroprotective, anti-inflammatory | Neuroprotection |
| Spermidine | Triggers autophagy & cellular cleanup | Regeneration / Longevity |
| Methylfolate | Methylation, DNA synthesis, homocysteine metabolism | Methylation |
| Methyl-B12 | Energy metabolism, methylation, nerve function | Methylation |
| CMED 100 | Telomere support, DNA protection | Cellular protection |
Noteworthy:
- Some ingredients like Ergothioneine, PQQ, and CMED 100 are rarely found in conventional multivitamins.
- Others – such as NR, Resveratrol, and Spermidine – have become staple components in advanced longevity stacks.
- Life I/O is unique in the synergistic combination of these molecules, aiming to support both mitochondrial efficiency and genomic integrity.
What Sets Life I/O Apart?
Unlike many longevity supplements that rely on brand recognition or a kitchen-sink approach, Life I/O follows a more targeted logic:
It’s not an all-in-one green powder like AG1, but rather a focused stack of well-curated molecules.
Classic Meets Cutting-Edge
The formula combines established compounds such as Resveratrol, CoQ10, and Quercetin with emerging bioactives like Ergothioneine, PQQ, and CMED 100 – some of which are just starting to gain attention in the scientific community.
Clear Purpose, No Overload
Life I/O is built around three biological priorities:
- Mitochondrial Function – via NR, PQQ, CoQ10 to support cellular energy production.
- Cell Protection & Antioxidant Defense – using Quercetin, Resveratrol, and Ergothioneine to reduce oxidative stress.
- Methylation & DNA Stability – with Methyl-B12, Methylfolate, and CMED 100 to support epigenetic regulation and repair.
This selective focus makes Life I/O appealing to users who want precision longevity support rather than a broad-spectrum formula.
Are There Studies or Evidence?
No studies on the full Life I/O product have been published yet – which isn’t unusual for new launches.
However, many of the individual ingredients are well-documented:
- NR (Nicotinamide Riboside): Several human trials show increases in NAD+ and improved mitochondrial markers.
- Spermidine: Studied for its role in autophagy and healthy aging.
- Quercetin, Resveratrol, CoQ10: Extensively researched antioxidants.
- CMED 100 & Ergothioneine: Less clinical data, but promising preclinical findings.
Bottom line: While there is no clinical data yet on Life I/O as a formula, the components are supported by a growing body of research.
Who Is Life I/O For?
Life I/O isn’t aimed at beginners or casual supplement users. It targets those who want to invest in cellular health and healthy aging.
It may appeal to:
- Biohackers focused on prevention, resilience, and performance
- Adults 30+ with stress-related energy issues
- People seeking a compact stack instead of 10 separate bottles
It’s important to note: Life I/O is not a miracle pill. It complements, not replaces, healthy sleep, exercise, and nutrition.
Pricing: Is It Worth It?
At €89.90/month, Life I/O is clearly a premium product. But a comparison shows:
Buying all of these compounds separately at similar quality levels would easily cost €150/month or more – not including the hassle of sourcing and dosing.
For those committed to targeted longevity support, Life I/O could be a well-designed and cost-efficient alternative.
Personal Experience (Coming Soon)
As of now, Life I/O is not yet available, especially outside of select launch regions.
We plan to test the product as soon as it becomes accessible, and will update this section with practical experience and biomarker data (e.g. HRV, sleep, focus, subjective energy).
Final Verdict: Is Life I/O Legit?
Life I/O isn’t your average multivitamin. It’s a targeted longevity supplement, built on emerging science and a smart ingredient profile.
It’s not for everyone. But if your focus is on mitochondria, methylation, and cellular resilience, it might be worth keeping an eye on.
It’s not available yet – but the concept looks promising.
Whether it lives up to its claims will be seen once real-world testing begins.
